CONFERENCE PROGRAMME BASED ON THE VISION AND FOUNDATIONAL WORK OF PROFESSOR GÉRARD SIEST † IN PROMOTING AND MEDIATING PERSONALISED MEDICINE / 1936-2016
On April 9th, the entire world of laboratory medicine lost a dominating figure, a pioneer, and an innovator in the field. Gérard Siest passed away just before his 80th birthday in an unexpected and unpredictable manner.
Prof. Siest was Emeritus Professor of molecular biology and biochemical pharmacology at the Faculty of Pharmaceutical Sciences and former director of the postgraduate course in Biochemical Pharmacology at the University Henri Poincaré in Nancy (currently “Université de Lorraine”), France. During his brilliant academic carrier, he became the founder and head of the clinical laboratory and research group of the “Centre de Médecine Preventive” in Nancy for 37 years (1968-2005) and the Director of a research lab at the Faculty of Pharmacy called “Centre du Médicament”.
As an extremely hardworking person Prof. Gérard Siest was well known to the scientific community as author of more than 800 publications in peer reviewed journals and his work was honored by 27 awards from sixteen different countries. He was strongly involved in activities of many International and European professional societies. He served as President of IFCC (1991-1996). Since 2011, he was dedicated to the foundation of the European Society of Pharmacogenomics and Personalised Therapy (ESPT), which under his inspired leadership has gained worldwide visibility and is currently an important scientific stakeholder in the field of pharmacogenomics and personalised medicine. After organizing for many years the “Pont à Mousson – Biologie Prospective” international meetings, he was dedicated to the continuous organization of the ‘Santorini conferences’ on personalized medicine, which he founded in 2002.
His editorial activities encompass a range of important appointments, such as Editor-in-Chief of Clinical Chemistry and Laboratory Medicine (1998-2008), Editor-in-Chief of Drug Metabolism and Personalized Medicine (2010-2015), and member of the Editorial Boards of many other European and international journals.
He also received numerous international prices and awards.
Only once, every one or two generations, a brilliant mind emerges with all the talent, vision and personal characteristics capable of influencing entire fields of science. Gérard Siest was just one of these people. Gérard was called “the man with eternal smile” − to highlight a trait of his character − so dynamic, full of energies, but always open for discussions and sharing visions and projects with many other scientists.
Gérard’s sudden death leaves a huge gap in the scientific community. We have lost a unique clever and talented Colleague and Mentor, an exceptional and innovative scientist, a pleasant friend and a full of life and energy beloved husband.
We will miss Gérard, his tireless enthusiasm, his determination, his visionary leadership and friendship, but we will always honor his memory by assuring the continuity of his work. It’s the reason why the “Santorini Conference” 2016 will run and we will do our best to make it a success with all of you.
Sofia Siest & all the INSERM U1122 Unit team “Gene-Environment Interactions in Cardio-Vascular Physiopathology” (IGE-PCV)
WELCOME / Message from Sofia Siest and Gerard Siest †
Dear colleagues, dear friends,
We have simulating conference program wich will be completed by the last arrived abstract.
It will be organized in close collaboration with ESPT. After the most successful 2014 conference ever with the highest number of participants we are planning again with the scientific committee a 3 days meeting:
Starting the first day with Systems Medicine we have 2 specific clinical prospective sessions.
A second day devoted to the phenotypes importance in the studies of physiological variations chronic diseases and under the environment effects, particularly nutrition.
The last day, sessions will be constructed around personal therapy with the use of the new genomic data. The recent introduction of new drugs and development of biological pathways also are interesting topics.
We are now waiting the abstracts for posters presentations until may 14
SANTORINI is an inspiring island for thinking about the future of Personalised Health and Individual Therapy.
Scientific Topics The Santorini Conferences are bringing together scientists from various origin interested in genetics and biological variations in man and its impact on the origin, prediction, prevention, diagnosis and therapy of human multifactorial disorders. The first event, held in 2002, was opened by Jean Dausset’s notes on predictive medicine and a lecture by Klaus Lindpaintner on the “Impact of Genetics and Genomics on Health Care”.
The second conference, in 2004, had Doug Wallace’s opening lecture on “Mitochondrial DNA Diversity in Health and Disease” as one of its notable highlights. The third conference, held in 2006, focused on the identification of novel molecular biomarkers as enabled by “Omics” approaches. Conferences in 2008, 2010, 2012 and 2014 were oriented around the concept of systems biology and applications to personalized health and therapy (be it pharmaceutical or nutritional).
The integration of Omics with genetics hold great potential to better understand the complex interplay between static genetic pre-disposition and dynamic environmental effects (e.g. nutritional, infections, xenobiotics) and the consequences for health maintenance, disease development and personalized therapy. Although progress has been made in our understanding of population variation and associated risk factors, in complex diseases, such as cancer, atherosclerosis, diabetes and brain disorders, their understanding remains the biggest challenge. Inflammation is often one of the major players. However changes in lifestyle and other environmental conditions, combined with genetic predisposition, appear to underlie the most recent epidemics of chronic disease and may hold the key to influencing the trends in their incidence and management. In addition, infectious diseases particularly viral ones represent an important aspect of environment influence. Technological advancements have been profuse and must be considered as the foundation of current and future progress. Modern sequencing platforms, microarrays, high-throughput SNP detection technologies, gene transcript profiling, quantitative multiplexed proteomics, metabolomics analysis and cellular models are indispensable tools driving the rapid progress in personalized treatment and intervention.
The organization of an ever increasing information load is becoming as important as generating the underlying raw data. Establishing and managing databases and further improving the tools to retrieve, visualize, validate, interpret and cross-correlate the data are therefore becoming essential components in this scenario. Modelisation is necessary. It will be important and necessary to develop new specific softwares for predicting risk and interpreting the large amount of data. All these aspects are linked in the systems biology/systems medicine approach.
One of the greatest obstacles remaining is the setting up, funding and monitoring of large prospective, population-based cohort studies, comprising possibly several hundred thousand individuals, from whom DNA, plasma and cells will have to be collected and established in biobanks associated with high quality clinical data, GWAs are then possible. Upgrading diagnostic laboratories to incorporate these new technologies is already taking place. However, despite tremendous scientific efforts, as represented by the unprecedented speed with which new data are being generated, surprisingly little molecular research has so far been successfully translated into clinical practice. This deceiving finding has several reasons: (i) Data do not equal information: the translation of the raw measurements into interpretable and actionable read-out is challenging; (ii) Omics can deliver biomarker and target candidates without pre-conception; however, these candidates need to be validated and managed within research pipelines; (iii) the acceptance of the new holistic concepts by health care professionals represents one of the major hurdles impeding the use of available pharmacogenetic/nutrigenetic/- genomic knowledge in reaching better informed treatment decisions.
Thus, it appears important not only to foster translational research but also to enable concurrent development and implementation of the necessary educational tools. The latter should ensure that molecular and personalized medicine/treatment is taught well and systematically applied in today’s health care systems. Whilst most would agree that this transition will take time, there is, however, no time to lose. On the basis of this introduction, our objectives, both general and specific, for the 2016 conference are outlined below: Bridging Omics And Genetics in a system biology approach To study the networks of interacting genes, proteins and biochemical reactions in physiological states or variable illnesses, particularly cardiovascular diseases, Alzheimer, infections and cancer).
To analyse the functional significance of gene polymorphisms and protein isoforms by studying gene and protein networks, and to link them to health maintenance, diseases predisposition or personalized therapy. To increase the knowledge of the interplay between genetic disposition, environment including infection (viral, bacterial, parasitological), nutritional factors and drug intake. To compare the results obtained by genome wide association studies with the case-control ones. To address the use of blood cells as a source of information and their exploitation as “sentinels” in the above contexts. To communicate state-of-the-art information on molecular markers for multifactorial diseases, pharmacogenomics and personalised medicine. To evaluate the comparison of diagnostic approach To assess the suitability of these markers for the prediction of physiological deviations such as obesity, of other disease risks and of drug response, including adverse side effects, at individual or population level.
To describe emerging laboratory tools for molecular analysis and their combination with imaging technologies for comprehensive health assessment including aging and monitoring of therapeutical intervention.
You have 2 options to go from Athens to Santorini:
That’s obviously the quickest and most expensive option.
It takes about 40-45 minutes by plane to be at Santorini’s small airport and it definitely worths it in our opinion.
For 2016, the following companies operate direct flights from Athens to Santorini:
1. Aegean Airlines (proposed)
fly directly to Santorini from other European cities (especially between April-October):
Niki (from Vienna)
Thomas Cook (from Birmingham, Gatwick, Manchester, Brussels)
Thomson (from Birmingham, Gatwick, Manchester, Bristol)
Volotea (from Venice, Bari, Naples, Palermo)
Germanwings (from Cologne)
Norwegian (from Oslo, Copenhagen, Stockholm)
Transavia (from Paris,
British Airways (from London Heathrow)
Condor (from Munich, Hamburg, Stuttgard,, Dusseldorf, Franfurt)
Aegean (from Moscow)
Easyjet (from Rome, Milan, Geneva, Manchester, Gatwick)
Vueling (from Barcelona, Bilbao)
Jetairfly (from Brussels)
HolidayJet (from Zurich)
You have to go to the Athens ferry port which is called Piraeus.
The easiest and cheapest option is by taking the bus X96 that stops just outside of the Athens airport. It takes between 50 mins to 80 mins (depending on the traffic).
Santorini Ferries depart from E7 Port Gate so you have to stop at the bus station : STATION ISAP (ΣΤΑΘΜΟΣ ΗΣΑΠ) (which is also a metro station). The X96 bus runs 24/7 and there is a bus every 30 mins.
For adults the ticket costs 5 euros and for kids it costs 2.5 euros.
Avoid the fast and smaller ferries. Take the slowest and bigger ferries to Santorini. They may take a few more hours to take you to your destination but you may save yourself from sea sickness and a bumpy ride.
Our suggestion is to go to Santorini by plane because it’s generally much faster and simpler but you can also take the ferry which can be a very interesting option
From the airport you can take a taxi or take a private shuttle or a local bus or you can rent a car.
taxis : 0030 22860 02 2555 or 0030 22860 03 3951.
At last you can rent a car for a day or your full stay at a nice price.
Contact info: email@example.com
Touring the island by motorbike is a popular choice for holiday makers. Economical, easy to park and capable of navigating most of Santorini's volcanic terrain. Fira the capital and other prominent villages on the island have free public parking areas. Use them to avoid traffic congestion and parking fines. From the other hand, you are advised not to hire motorcycles, scooters, mopeds or quad bikes, as accidents involving these forms of transport are very common
Do you need accommodation?
Ira Hotel & Spa
Firostefani, Santorini 84 700 Greece
Tel.: +30 22860 28835,
EVGENIA VILLAS & SUITES
Fira, Santorini, GR 84700
Tel: +30 2286022575
The Reverie HotelFirostefani, Santorini isl. Cyclades,Greece, P.C. 84700
Tel +30 22860 23322,
If you need assistance to book your hotel please send an email to Etienne Jarry
Restaurant “Pyrgos” welcomes you to Santorini and the beautiful village of Pyrgos. Situated in an idyllic location overlooking the entire island, restaurant “Pygos”, for 25 years, has been serving the finest products from the land and the sea from the island of Santorini.
With respect to every aspect of Santorini’s and traditional cuisine, restaurant “Pyrgos” has been established on the island as one of the best restaurants serving from early morning till late at night. While the exquisite banquet halls are covering your organizing needs for an unforgettable wedding reception and any other event.
Restaurant “Pyrgos” in Santorini is built on levels, with large windows and stands as an observatory at the entrance of Pyrgos village, which is at the center of the island. From all areas of the restaurant “Pyrgos” you can enjoy great views across the island of Santorini, and also the unique and famous sunset of Santorini.
Restaurant “Pyrgos” after the renovation in 2009 has specially designed reception halls with all necessary facilities to organize a wedding reception, and any kind of event. The halls of the restaurant “Pyrgos” can accommodate up to 600 people. The special menus, the impeccable service, the experienced staff and the specialized approach to every single event guarantee a truly memorable experience for you and your guests.
Whatever brings you to the restaurant “Pyrgos” you will definitely enjoy a wonderful and representative experience of Santorini’s hospitality with unique flavors and friendly service.
This program includes both the fundamentals of pharmacogenomics as well as the latest knowledge on established and novel concepts in the field, as well its advanced clinical applications, and it does not require previous knowledge and experience in the field. Participants in